Captopril: instructions for use
"Captopril" is a medicinal product of the group of ACE inhibitors, which is used to treat chronic heart failure and hypertension. The product is available in the form of tablets.
Composition and pharmacological action
One tablet of Captopril contains 25 or50 mg of the active ingredient, as well as auxiliary substances: corn starch, lactose, magnesium stearate and talc. "Captopril" has a vasodilating effect, which reduces the overall peripheral resistance of the vessels, and increases the minute volume of blood flow and exercise tolerance. With long-term treatment, the drug helps to reduce the severity of myocardial hypertrophy and improve the blood supply of the ischemic myocardium.Dosing and Administration
Tablets "Captopril" should be taken one hour beforefood. The dose is set individually. Recommended starting dose for Captopril is 25 mg twice a day. In the future, it can be increased. Increase in the dose is carried out gradually, with observance of intervals from 2 to 4 weeks. With arterial hypertension of a mild and moderate form, the maintenance dose is 25 mg 2 times a day. The maximum permissible single dose of "Captopril" in this case is 50 mg. With arterial hypertension of severe form, the patient can be given the maximum dose of the drug: 50 mg 3 times a day. When treating chronic heart failure, a dose of 25 mg is applied, which should be taken 2 or 3 times a day. With insufficient therapeutic effect, the dose can be gradually increased up to the maximum. Patients with severe renal dysfunction at the beginning of therapy should be prescribed not more than 12.5-25 mg of the drug per day. If necessary, the daily dose can be increased with observance of long intervals between increases.Contraindications and side effects
The use of the drug is contraindicated whenHypersensitivity to the components, during pregnancy and breastfeeding, as well as in the treatment of children and adolescents under the age of 18 years. In addition, "Captopril" is not prescribed for the following diseases and disorders: - arterial hypotension, - angioedema, - history of kidney disease, renal and hepatic manifestations, - mitral stenosis, stenosis of the aortic aorta and other pathologies that result in the outflow of blood from the left ventricle of the heart is violated, - cardiogenic shock. "Captopril" is prescribed with caution in old age, with severe autoimmune diseases, diabetes, ischemia of the heart and brain, oppression of bone marrow krovoto rashchenija, hemodialysis, as well as conditions in which reduced the volume of circulating blood, including vomiting and diaree.Pobochnye the drug may manifest as tachycardia, pronounced decrease in blood pressure, orthostatic hypotension, peripheral edema, renal dysfunction and proteinuria. Dizziness, headache, drowsiness, asthenia, fatigue, visual impairment, cough, bronchospasm, pulmonary edema and allergic reactions are also possible. In a number of cases, patients experience dry mouth, taste changes, nausea, stomatitis and decreased appetite.
